We broke down the NFL Week 6 odds and picked every game. We have picks against the spread, moneylines, and Over/Unders for NFL Week 6.

Week 6 doesn’t have any games for any teams except the Green Bay Packers and the Pittsburgh Steelers. During their bye weeks, they have 15 games set.

The first game of the week was Thursday Night Football in Kansas City, Missouri. The Denver Broncos played the Kansas City Chiefs at Arrowhead Stadium, and KC won 19–8.

This is where we can find the most up-to-date odds and make our early NFL Week 6 picks. Our A.I. NFL picks page has even more picks for NFL Week 6.

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Here are the NFL Week 6 odds from YouWager for games this Sunday:

Baltimore Ravens vs. Tennessee Titans NFL Week 6 Odds

Baltimore Ravens -4.5 (-110) -220 Over 42 (-110)
Tennessee Titans +4.5 (-110) +180 Under 42 (-110)

The Ravens just got back from a tough road game against Pittsburgh, which was a rematch. They are still on the road in Week 6 because they play the Titans in London.

At times, Baltimore has looked like a good choice to win the AFC and go to Super Bowl 58. It would be a shock if they even made the playoffs, though, because they don’t always look like they can score.

The Titans haven’t been good at stopping passes lately, but they should be able to do it against the Ravens.

We want a game with field goals. It’s likely that you should check out the enemy’s points at London’s Tottenham Hotspur Stadium.

Ravens vs. Titans Prediction:

  • Point Spread Bet: Tennessee Titans +4.5 (-110)
  • Moneyline Bet: Tennessee Titans (+220)
  • Over-Under Bet: Under 42 (-110)

Washington Commanders vs. Atlanta Falcons NFL Week 6 Odds

Washington Commanders +2 (-110) +115 Over 42.5 (-110)
Atlanta Falcons -2 (-110) -135 Under 42.5 (-110)

The Commanders aren’t easier to understand than any other NFL team. Which team shows up after being embarrassed by the Bears in prime time?

Their defense won’t work well on the road, even though they’ve had more time to get ready.

There’s no doubt that the Falcons have not been the most attractive football team lately. They should be able to win a bad football game at home with the help of Bijan Robinson and Tyler Allgeier, though.

Commanders vs. Falcons Prediction:

  • Point Spread Bet: Atlanta Falcons -2 (-110)
  • Moneyline Bet: Atlanta Falcons (-135)
  • Over-Under Bet: Under 42.5 (-110)

Indianapolis Colts vs. Jacksonville Jaguars NFL Week 6 Odds

Indianapolis Colts +4 (-110) +175 Over 44.5 (-110)
Jacksonville Jaguars -4 (-110) -210 Under 44.5 (-110)

The Colts are ready to start Gardner Minshew, who used to play quarterback for the Jaguars, because Anthony Richardson is hurt. I worked with the Jaguars from 2019 to 2020, and he won a few big games.

He can put the Colts ahead in the AFC South with a win over the Jaguars. When Minshew gets back to Jacksonville, he’ll be fired up.

The Jaguars may not be as excited about this divisional game since they just got back from London with a big win. The Colts will play hard, but the Jaguars should come out on top.

Colts vs. Jaguars Prediction:

  • Point Spread Bet: Indianapolis Colts +4 (-110)
  • Moneyline Bet: Jacksonville Jaguars (-210)
  • Over-Under Bet: Under 44.5 (-110)

Minnesota Vikings vs. Chicago Bears NFL Week 6 Odds

Minnesota Vikings -3 (-105) -155 Over 43.5 (-110)
Chicago Bears +3 (-115) +135 Under 43.5 (-110)

Even though their 40–20 win over the Commanders was great, the Bears have a lot of sickness. A lot of stars and even second-year players were out on both sides of the ball.

Even though the Bears have had more time to prepare for Week 6, they are still sick. But the Vikings might not have Justin Jefferson, their star wide receiver.

When the Vikings are on attack, Jefferson is their most important player. Kirk Cousins can run the ball when Jefferson is on the field. If he can’t start, it will be hard for the Vikings to score.

The Bears now have the ball at home. If the Vikings don’t have Jefferson, Justin Fields should be able to beat them with D.J. Moore. For this one, you should read the story about the accidents.

Vikings vs. Bears Prediction:

  • Point Spread Bet: Chicago Bears +3 (-110)
  • Moneyline Bet: Chicago Bears (+135)
  • Over-Under Bet: Over 43.5 (-110)

San Francisco 49ers vs. Cleveland Browns NFL Week 6 Odds

San Francisco 49ers -10 (-110) -500 Over 36 (-110)
Cleveland Browns +10 (-110) +400 Under 36 (-110)

In Week 6 of the NFL season, a lot of people who bet on football are likely to back the 49ers.

After their big game against the Cowboys on Sunday Night Football, the 49ers might not be as ready to go. Also, they might be tired from going east to Cleveland.

No one seemed to know why Deshaun Watson was scratched before the game against the Ravens two weeks ago. He should be ready to go after the week off.

But the 49ers were busy with the Cowboys and didn’t have time to prepare for this game. The Browns did. As long as Watson is healthy enough to play again, the Browns’ pass rush should keep them in the game.

49ers vs. Browns Prediction:

  • Point Spread Bet: Cleveland Browns +10 (-110)
  • Moneyline Bet: San Francisco 49ers (-500)
  • Over-Under Bet: Under 36 (-110)

Seattle Seahawks vs. Cincinnati Bengals NFL Week 6 Odds

Seattle Seahawks +3 (-115) +130 Over 45 (-110)
Cincinnati Bengals -3(-105) -150 Under 45 (-110)

Arizona was a win for the Bengals. Could this be the beginning of a run? Joe Burrow and Ja’Marr Chase were able to get into a flow that made them look at ease, even though it wasn’t perfect.

But it wouldn’t matter if the Bengals can’t beat the Seahawks at home.

Burrow does not play at his best, even though he looked good. The shoes sometimes wrapped around his leg on the side. Picture the Seahawks in a close game.

Seahawks vs. Bengals Prediction:

  • Point Spread Bet: Seattle Seahawks +3 (-115)
  • Moneyline Bet: Seattle Seahawks (+130)
  • Over-Under Bet: Over 45 (-110)

New Orleans Saints vs. Houston Texans NFL Week 6 Odds

New Orleans Saints -1.5 (-110) -125 Under 42.5 (-110)
Houston Texans +1.5 (-110) +105 Under 42.5 (-110)

It was a big win for the Saints because they beat the Patriots 34-0. Now they’re going to Houston to play the Texans, who lost a close game in Atlanta 21–19.

They lost a close game in the last second. Now they have to play at home against the Saints’ strong defense. On top of that, Alvin Kamara’s comeback has made the attack stronger.

They want their offensive line to be in good shape for this game. It should be hard to do things the way they are now. This is where the Saints should be able to hold on.

Saints vs. Texans Prediction:

  • Point Spread Bet: New Orleans Saints -1.5 (-110)
  • Moneyline Bet: New Orleans Saints (-125)
  • Over-Under Bet: Under 42.5 (-110)

Carolina Panthers vs. Miami Dolphins NFL Week 6 Odds

Carolina Panthers +14 (-110) +650 Over 47.5 (-110)
Miami Dolphins -14 (-110) -1000 Under 47.5 (+110)

It would be better for Bryce Young to learn from a quarterback with more experience. Young can’t do that because he was picked first in the 2023 NFL Draft, which is too bad.

Frank Reich isn’t getting much help from his coaching staff because they are calling plays. Young still needs to do better at Miami. He could play some plays, but not enough to keep up with Tua Tagovailoa.

It was a game between two new Alabama quarterbacks, and Tagovailoa and the Dolphins won. The Vikings lost to the Lions 42–24 last week, and it looks like they will lose again in Week 6.

Panthers vs. Dolphins Prediction:

  • Point Spread Bet: Miami Dolphins -14 (-110)
  • Moneyline Bet: Miami Dolphins (-1000)
  • Over-Under Bet: Over 47.5 (-120)

New England Patriots vs. Las Vegas Raiders NFL Week 6 Odds

New England Patriots +3 (-110) -130 Over 41.5 (-110)
Las Vegas Raiders -3 (-110) -150 Under 41.5 (-110)

People know that Bill Belichick and the Patriots set new records. Thus far this season, the teams have had bad luck. They have lost their first four games and are now 1-4. Both of their most recent games were blown out.

The things that Mac Jones did wrong have made his life very bad, and he doesn’t have the tools to fix them. The defense is also different from what we’ve come to expect from Belichick.

It’s likely that Jimmy Garoppolo will beat his old team at home in Las Vegas. People shouldn’t cheer for the Patriots if they don’t try to win.

Patriots vs. Raiders Prediction:

  • Point Spread Bet: Las Vegas Raiders -3 (-110)
  • Moneyline Bet: Las Vegas Raiders (-150)
  • Over-Under Bet: Under 41.5 (-110)

Detroit Lions vs. Tampa Bay Buccaneers NFL Week 6 Odds

Detroit Lions -3 (-110) -155 Over 42.5 (-110)
Tampa Bay Buccaneers +3 (-110) +135 Under 42.5 (-110)

After a week off, the Buccaneers will be ready for their next game, which will be against the Lions. They need to do their jobs because if they don’t, the Lions could score quickly.

They played well after the break and beat the Saints 26–9. Derek Carr was only able to throw 127 yards. This was a good response after losing 25–11 on Monday Night Football.

The Buccaneers are 3-1, but they will have a tough game. I think they will win in the end, though. With odds of + points, the Buccaneers are a great bet to win NFL Week 6.

Lions vs. Buccaneers Prediction:

  • Point Spread Bet: Tampa Bay Buccaneers +3 (-110)
  • Moneyline Bet: Tampa Bay Buccaneers (+135)
  • Over-Under Bet: Under 42.5 (-110)

Philadelphia Eagles vs. New York Jets NFL Week 6 Odds

Philadelphia Eagles -6 (-110) -285 Over 41 (-110)
New York Jets +6 (-110) +232 Under 41 (-110)

They’re coming to town, and the Jets are ready to greet them. They were just back from a tough win in Denver. The Eagles will be much tougher than the Broncos.

Zach Wilson will likely not be able to breathe on Sunday because of the Eagles’ defense. People didn’t think the Jets’ defense would be this good, but it’s not good enough to beat the Eagles.

They will show the Jets who’s in charge with their pass rush. They should get ahead and win by at least a touchdown at MetLife Stadium.

Eagles vs. Jets Prediction:

  • Point Spread Bet: Philadelphia Eagles -6 (-110)
  • Moneyline Bet: Philadelphia Eagles (-285)
  • Over-Under Bet: Under 41 (-110)

Arizona Cardinals vs. Los Angeles Rams NFL Week 6 Odds

Arizona Cardinals +7 (-110) +245 Over 48.5 (-110)
Los Angeles Rams -7 (-110) -310 Under 48.5 (-110)

At the goal line, the defense stood up, and Dobbs threw a pick-6. The Cardinals may have lost faith after this. Joe Burrow took the Bengals’ chance to pull away for a must-win game in the desert.

That was a tough game against the Eagles’ defense. The Cardinals will be a lot easier for Matthew Stafford and the rest of the team.

While the Cardinals had a good start to the season, they likely thought they were better than they were. You can bet that the Rams will win at home and cover the spread.

Cardinals vs. Rams Prediction:

  • Point Spread Bet: Los Angeles Rams -7 (-110)
  • Moneyline Bet: Los Angeles Rams (-310)
  • Over-Under Bet: Over 48.5 (-110)

New York Giants vs. Buffalo Bills NFL Week 6 Odds

New York Giants +15 (-110) +825 Over 44 (-110)
Buffalo Bills +15 (-110) -1200 Under 44 (-110)

The Bills had a terrible trip to London! They’re back in the US now. The Bills were very tired from their trip, which helped the Jaguars beat them 25–20.

The Giants are the best team to play after a bad loss. They’ve lost three straight games by more than 10 points, and when they’re on the road, they’re down 15 points. The bookmakers believe that Orchard Park will lose.

Because Daniel Jones hurt his neck, he is going to get an MRI. If he can’t, Jones will start next. This season, Jones hasn’t been great, so Taylor might not be that much worse.

Though Saquon Barkley has missed three games in a row, the Giants are hopeful that he will be able to play again. The Bills’ linebacker Matt Milano and defensive tackle Daquan Jones both got hurt in London and had to leave. The Bills’ defense is getting worse, and Tre’Davious White is already out.

If Barkley starts, the Giants should be able to finish the game. There’s no way they can win, but they can cover an unfair point spread.

Giants vs. Bills Prediction:

  • Point Spread Bet: New York Giants +15 (-110)
  • Moneyline Bet: Buffalo Bills (-1200)
  • Over-Under Bet: Over 44 (-110)

Dallas Cowboys vs. Los Angeles Chargers NFL Week 6 Odds

Dallas Cowboys -2 (-110) -135 Over 51 (-110)
Los Angeles Chargers +2 (-110) +115 Under 51 (-110)

The Bears had a strong pass rush, but the 49ers’ offensive line was strong enough to hold up. The Chargers might protect Justin Herbert, but we’re not sure.

The Chargers had a week off, but that won’t help them get ready for the Cowboys’ defense led by Micah Parsons.

There’s also no doubt that the Chargers’ defense will be tougher to beat than the 49ers’. They had one of the best records in the league before, but now they have the worst record.

Every game, the Chargers have let receivers gain about 300 yards. To end Week 6, both Dak Prescott and CeeDee Lamb will play in big games on Monday Night Football.

Cowboys vs. Chargers Prediction:

  • Point Spread Bet: Dallas Cowboys -2 (-110)
  • Moneyline Bet: Dallas Cowboys (-135)
  • Over-Under Bet: Over 51 (-110)

NFL Week 6 Best Bet

They have given up 100 points in their last three games. They let the Seahawks score 37 points and the Lions score 42 points.

They won’t get better when they play the best offense in the NFL, that’s what we think. Their defense, led by Tyreek Hill and Jaylen Waddle, will make it easy for Tagovailoa and the fast-paced Dolphins’ attack to beat them.

They’ve scored at least 31 points in two of their home games. In Week 3, they scored 70 points against the Broncos. In Week 4, they only scored 20 points as they played Buffalo. On the other hand, the offense started up where it left off at Hard Rock Stadium.

They’ve lost a lot of games when teams can run the ball. After the Dolphins run the ball down their throats, they can start to pass.

It’s likely that the Over will win, but we like the Dolphins vs. the spread. Bryce Young needs to say what’s on his mind. The Panthers aren’t sure if they’ll be able to stay in the game with their running backs.

At Alabama in Week 6, Tagovailoa and Young will play against each other. It should be a lot of fun.

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2023 NFL Week 6 Odds and Predictions by YouWager.lv.